Scalice was born Francesco Scalisi in Palermo, Sicily, Italy on September 23, 1893, to Vincenzo Scalisi and Emanuela Privetera. He was a cousin of Anthony Gaggi's father, and third cousin of Dominick Montiglio, Gaggi's nephew. +more In 1910s, with his brothers Thomas, Philip, Jack, Joseph and Giovanni, Frank emigrated to the United States, settling in The Bronx. He was married to Joan, and he had five daughters and one step-son. He operated his business from the Little Italy area in the Bronx. He also lived and raised his family in the City Island section of the Bronx. He was involved in many crimes and became Capo in the Brooklyn-based gang of Salvatore D'Aquila. After the murder of D'Aquila on October 10, 1928, the power in New York shifted to Joe Masseria's Manhattan-based gang. The successor of D'Aquila, Manfredi Mineo, connected Masseria with the alliance and came into conflict with Scalice as a result.
On November 5, 1930, Mineo and his underboss, Stefano "Steve" Ferrigno, were murdered by Castellammarese Sicilians, led by Salvatore Maranzano. Scalice became the new boss of the family and a strong ally and supporter of Maranzano in the Castellammarese War.
The Castellammarese War ended on April 15, 1931, when Masseria was killed. Maranzano met with the New York bosses in May 1931 to work out a peace plan and organize the Five Families. +more Scalice was recognized as the Don of one of the families. However, after the murder of Maranzano on September 10, 1931, new boss Lucky Luciano forced Scalice to resign as family boss. He was replaced with Vincent Mangano.
During the Mangano era, Mangano had resented Albert Anastasia's close ties to Luciano and Frank Costello, particularly the fact that they had obtained Anastasia's services without first seeking Mangano's permission. This and other disputes led to heated fights.
Mangano's brother Philip was found dead near Sheepshead Bay, Brooklyn on April 19, 1951. Vincent Mangano disappeared, he was never found and was declared dead ten years later. +more It was widely assumed that Anastasia had them killed.
After the deaths of the Manganos, Anastasia became the boss of the family, promoting Scalice as underboss.
On June 17, 1957, Scalice was assassinated by two gunmen at a vegetable market in the Bronx, for selling memberships in the family. Scalice's funeral was held at the Scocozza Funeral Home in the Bronx. +more Police and federal agents attended the funeral and the Bronx District Attorney subpoenaed all the visitor records. Scalice is buried in Woodlawn Cemetery in the Bronx.
After his death, Carlo Gambino became Anastasia's underboss.
On September 7 of that year, Scalice's brother Joseph was murdered and declared missing on September 10. According to Joseph Valachi, he was killed by James Squillante, after he threats to avenge Frank's murder, and like that of his brother it was ordered by Anastasia.
On April 27, 1959, Scalice's brother Giovanni, who had been held as a witness in his brother's murder, was discharged, and took a plane to Paris.